郑大一附院李臻DEBTACE治疗消化

作者及单位

李臻，李鑫，白亮亮，纪坤，詹鹏超，任建庄，段旭华，韩新巍

医院放射介入科

郑州

本文引用格式

李臻，李鑫，白亮亮，等.DEB-TACE治疗消化道肿瘤肝转移的初步观察[J].郑州大学学报（医学版）,,54(5):-

关键词：载药微球；化疗栓塞；肝转移；介入治疗

摘要目的:探讨载药微球(DEB)-经动脉化疗栓塞术(TACE)治疗消化道肿瘤肝转移的可行性、安全性及近期疗效。方法:48例经影像学或病理学确诊的消化道肿瘤肝转移患者，其中25例接受DEB-TACE治疗，23例接受传统TACE(c-TACE)治疗。DEB-TACE组男20例，女5例，年龄31~75(59.9±3.3)岁，包括结直肠癌肝转移17例、胃癌肝转移8例。c-TACE组中男15例，女8例，年龄27~77(60.1±10.0)岁，包括结直肠癌肝转移16例，胃癌肝转移7例。比较两组患者术前、术后1周、术后1个月肝肾功能、凝血功能、血常规等指标。术后1、3、6个月复查影像学(CT/MRI平扫+增强)，按改良实体瘤疗效评价标准评价近期疗效。结果:DEB-TACE组和c-TACE组患者术后1周均表现出ALT及白细胞—过性升高，术后1、3、6个月的疾病客观缓解率(80%、52%、27%vs65%、78%、13%)和控制率(84%、64%、41%vs78%、57%、22%)差异无统计学意义(P0.05)。两组患者均无严重并发症发生，栓塞后综合征(恶心、呕吐、腹痛、发热)发生率差异亦无统计学意义(P0.05)。结论：DEB-TACE治疗消化道肿瘤肝转移的近期疗效肯定，且安全、可行。ClinicalstudyofDEB-TACEintreatmentofdigestivetracttumorwithlivermetastasesLIZhen,LIXin,BAILiangliang,JIKun,ZHANPengchao,RENJianzhuang,DUANXuhua,HANXinweiDepartmentofInterventionalRadiology,theFirstAffiliatedHospital,ZhengzhouUniversity,Zhengzhou.

Keywordsdrug-elutingbead；chemoembolization；livermetastasis；interventionaltherapy

AbstractAim:Toexplorethefeasibility,safetyandshort-termefficacyofdrug-elutingbead(DEB)andtransarterialchemoembolization(TACE)inthetreatmentofdigestivetracttumorwithhepaticmetastases.Methods:Thedataof48patientswithlivermetastasesfromdigestivetractcancerwereretrospectivelyanalyzed.ThepatientswereallocatedintoDEB-TACEgroup(25cases)andc-TACEgroup(23cases).Therewere20malesand5femalesintheDEB-TACEgroup,aged31-75(59.9±3.3)years,including17casesofcolorectalcancerlivermetastasisand8casesofgastriccancerlivermetastasis.Therewere15malesand8femalesinthec-TACEgroup,aged27-77(60.1±10.0)years,including16casesofcolorectalcancerlivermetastasisand7casesofgastriccancerlivermetastasis.Theliverandkidneyfunction,bloodcoagulation，bloodroutineindicatorsofthetwogroupsbeforetheoperation,1weekaftersurgery,and1monthaftersurgery，were







































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